Malegra is typically taken about 30 minutes to 1 hour before anticipated sexual activity. It's essential to consult with a healthcare provider before using Malegra or any medication for erectile dysfunction. They can assess your health status, medical history, and any other medications you may be taking to ensure the medication is suitable for you. Response to medications can vary among individuals. Factors such as individual health, psychological factors, and the underlying cause of erectile dysfunction can influence the overall experience.