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Viagra, the brand name for sildenafil, is a medication primarily used to treat erectile dysfunction (ED) in men. Developed by Pfizer, it was initially intended as a treatment for hypertension and angina pectoris. However, during clinical trials, its significant effect on improving erectile function was discovered, leading to its approval for ED in 1998.\

Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which regulates blood flow in the penis. By blocking PDE5, sildenafil increases the levels of cyclic guanosine monophosphate (cGMP), which promotes relaxation of smooth muscle and increased blood flow to the corpus cavernosum, facilitating an erection in response to sexual stimulation.

Pharmacokinetics:

  • Absorption: Sildenafil is rapidly absorbed, with maximum plasma concentrations reached within 30 to 120 minutes after oral administration. Its bioavailability is about 40%.
  • Distribution: It is widely distributed throughout the body and is approximately 96% protein-bound in plasma.
  • Metabolism: Sildenafil is metabolized primarily by the liver enzymes CYP3A4 and CYP2C9. Its major circulating metabolite is also active.
  • Elimination: The half-life of sildenafil is about 3 to 5 hours. It is excreted primarily as metabolites in the feces (about 80%) and to a lesser extent in the urine (about 13%).

Administration:

Viagra is available in tablet form in doses of 25 mg, 50 mg, and 100 mg. The recommended starting dose for most men is 50 mg taken approximately one hour before sexual activity, but it can be adjusted based on efficacy and tolerability. It should not be taken more than once a day.

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