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It is crucial for one to observe the precautions associated with the use of tapentadol 100 mg. The drug should never be prescribed to those who have previously shown hypersensitivity to the said drug or any other opioids. This drug should not be used by those patients suffering from severe respiratory depression, acute or severe bronchial asthma, or paralytic ileus. Those patients with a history of substance misuse, liver or kidney impairment, and brain injury must take extra caution because tapentadol might worsen such cases. Combining the use of tapentadol with alcohol, benzodiazepines, or any central nervous system depressants could result in severe sedation, respiratory depression, and even death. The use of this drug by pregnant women is discouraged because of the risk of neonatal opioid withdrawal syndrome unless the benefits outweigh the risk. One should never stop the use of tapentadol suddenly to avoid withdrawals but gradually reduce dosage under medical supervision.

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