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The drug Phentermine is a sympathomimetic amine anorectic which is administered short term for the treatment of exogenous obesity. This drug was introduced in 1959, while the administration of its hydrochloride form began in the 1970s in order to treat obesity. It is indicated in patients who have obesity including some associated weight-related diseases. In this case, the drug should be administered along with other measures such as diet and physical activity.

Currently, Phentermine is extensively used on its own for short courses of treatment, but in 2012 it became FDA approved along with topiramate in order to treat chronic obesity. Nevertheless, monotherapy with Phentermine is still indicated for short terms (from several weeks to 12 weeks) after which the drug is stopped in order to avoid tolerance and side effects.

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