NephCure is a nonprofit organization supporting people affected by rare protein-spilling kidney diseases, including APOL1-associated kidney disease, C1q nephropathy, and C3 glomerulopathy (C3G).

What Causes APOL1-Associated Kidney Disease?

Understanding apolipoprotein l1 causes is important for anyone with recent West African ancestry. APOL1 kidney disease is linked to specific gene variants believed to have originated in West Africa generations ago. DNA testing is the only way to confirm risk

C1q Nephropathy Treatment

When it comes to c1q treatment, doctors typically manage the condition the same way as nephrotic syndrome — with steroids as the most common first approach, sometimes alongside other immunosuppressants. If remission isn't reached, ACE-inhibitors or ARBs may be added to reduce protein loss.

C3G Symptoms

Common c3g symptoms include blood in the urine, foamy or dark urine, fatigue, high blood pressure, swelling, and elevated protein or creatinine levels. Some children and young adults notice symptoms after a respiratory infection