Tadarise 60 mg contains tadalafil, a PDE-5 inhibitor. A 60 mg dose is higher than the usual maximum recommended dose for as-needed treatment of erectile dysfunction, so it should only be used under medical supervision.

Several over-the-counter (OTC) medicines and supplements may interact with tadalafil or increase its side effects. Decongestants such as pseudoephedrine or phenylephrine can affect blood pressure and heart rate, so caution is advisable, particularly in people with cardiovascular conditions. Some OTC antihistamines, especially those that cause drowsiness, may increase dizziness when combined with tadalafil.

OTC products marketed for sexual enhancement, erectile performance, or bodybuilding can be particularly concerning because some may contain undeclared sildenafil, tadalafil, or other active ingredients. Combining these with Tadarise can excessively lower blood pressure and increase adverse effects.

Certain herbal supplements, including products containing ginseng, yohimbe, or similar stimulants, may also affect blood pressure or interact unpredictably with tadalafil.

Tadarise 60 mg most important interactions involve nitrate medicines and certain prescription drugs, although these are generally not OTC products. Nitrates combined with tadalafil can cause a potentially dangerous drop in blood pressure.

Before taking Tadarise, tell your doctor or pharmacist about all OTC medicines, vitamins, and supplements you use. Do not combine tadalafil with another ED medicine unless specifically advised by a healthcare professional.